The calculation of an incremental cost-effectiveness ratio requires the estimation of the incremental effectiveness/utility/benefit of a technology relative to its comparator(s).

Estimation of the incremental effects can be based on information provided in the effectiveness domain (e.g. mortality data). Additional information collection may be needed (e.g. on health-related quality of life indices). The incremental effectiveness may result from an economic model, where inputs from the effectiveness domain are used (amongst others)

Overlap with effectiveness domain