Result card

  • EFF13: How does the treatment with adjuvant therapy on the basis of the test results of uPA/PAI, Mammaprint, or Oncotype compared to treatment on the basis of the standard practice in women diagnosed with early stage invasive breast cancer modify the magnitude and frequency of morbidity?
English

How does the treatment with adjuvant therapy on the basis of the test results of uPA/PAI, Mammaprint, or Oncotype compared to treatment on the basis of the standard practice in women diagnosed with early stage invasive breast cancer modify the magnitude and frequency of morbidity?

Authors: Authors: Mirjana Huic, Narine Sahakyan, Gurleen Jhuti, Anna Panasiuk, Heike Raatz, Petra Schnell-Inderst, Katarzyna Sejbuk, Eva Turk, Marjetka Jelenc

Internal reviewers: Luciana Ballini, Patricia Harrington, Stefan Lange, Michelle O'Neill, Paolo Giorgo Rossi, Stefan Sauerland, Luca Vignatelli, Siw Waffenschmidt

Acknowledgments: Jayne Hickton (Information Specialist, NICE)

No RCTs or prospective cohort studies on uPA/PAI-1, MammaPrint and Oncotype DX  tests were found that addressed how does treatment with adjuvant therapy on the basis of the test results of uPA/PAI-1, MammaPrint and Oncotype DX compared with treatment on the basis of standard practice in women diagnosed with early stage invasive breast cancer modify the magnitude and frequency of morbidity.

Please see the answer provided in the Assessment element question: EFF9 (D0025): What is the effect of adjuvant therapy on the basis of uPA/PAI-1, MammaPrint, or Oncotype DX test compared to treatment on the basis of standard practice in women diagnosed with early stage invasive breast cancer on overall survival and disease specific survival (for example: disease-free-, progression free-, recurrence-free-survival)?

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Huic A et al. Result Card EFF13 In: Huic A et al. Clinical Effectiveness In: Jefferson T, Vicari N, Raatz H [eds.]. Prognostic tests for breast cancer recurrence (uPA/PAI-1 [FEMTELLE], MammaPrint, Oncotype DX ) [Core HTA], Agenzia nationale per i servizi sanitari regionali (age.na.s), Italy ; 2013. [cited 2 December 2022]. Available from: http://corehta.info/ViewCover.aspx?id=113