Different factors could increase or decrease risk for colorectal cancer (CRC) {1,3,4}.

Factor which increased risk for CRC are: environmental factors (prevalence is increased in developed countries, urban areas); advantaged socioeconomic groups; hypercholesterolemia; coronary artery diseases; low-fiber, high-animal-fat diets; obesity; smoking; acromegaly; sugar consumption; family history (risk is increased in first-degree relatives of patients, families with increased prevalence of cancer, patients with breast or gynaecologic cancer, familial polyposis syndromes);>10-year history of ulcerative colitis or Crohns colitis;>15-year history of uretherosygmoidostomy.

Risk is decreased with long term dietary calcium supplementation, vegetable, garlic, exercise, daily aspirin ingestion (after 5 years daily aspirin there is a 35% reduction in all GI cancers) and other NSAIDs.